ОЦЕНКА БЕЗОПАСНОСТИ РЯДА РАСТИТЕЛЬНЫХ МЕТАБОЛИТОВ – ПЕРСПЕКТИВНЫХ ГЕРОПРОТЕКТОРОВ В ИССЛЕДОВАНИИ IN VIVO
Аннотация
Обоснование. Старение происходит наряду с прогрессирующим снижением физических функций организма и повышенным риском возрастных хронических заболеваний. Для лечения и профилактики хронических заболеваний в том числе используют полифенолы, например, мангиферин, кверцетин и транс-коричная кислота. Токсикологические исследования имеют важное значение в сфере биомедицинских исследований, так как некоторые экстрагированные полифенолы в высоких дозах могут способствовать развитию и прогрессированию рака и других заболеваний. Настоящее исследование направлено на оценку токсикологической безопасности выделенных ранее фенольных соединений из растений Сибирского Федерального округа.
Материалы и методы. В качестве модельного организма выбраны грызуны. Изучение мутагенных и антимутагенных свойств проводили при помощи микроядерного теста клеток костного мозга. Оценку цитотоксичности in vitro вели с помощью МТТ-теста.
Результаты. Изученные полифенолы в дозах 50,0 и 100,0 мг/кг не обладают мутагенными свойствами. Мангифери и кверцетин в дозе 50,0 мг/кг не обладают антимутагенным действием. При этом транс-коричная кислота в той же концентрации обладает антимутагенными действием. Мангиферин в концентрациях от 4,2 до 16,7 мкг/мл оказывает цитотоксическое действие. Транс-коричная кислота не обладает цитотоксичностью (при 2,1–33,3 мкг/мл). Кверцетин в концентрации 0,21 и 1,67 мкг/мл цитотоксическое действие, а в концентрациях 3,33 мкг/мл увеличивает жизнеспособность спленоцитов, предположительно за счет антиоксидантных свойств.
Заключение. Безопасность или низкая токсичность являются решающим преимуществом дальнейшего использования полифенолов в качестве перспективных геропротекторов. Установлено, что дальнейшее изучение биологически активных веществ (мангиферина, кверцетина и транс-коричной кислоты) является целесообразным.
Работа выполнена в рамках государственного задания по теме «Разработка биологически активных добавок, состоящих из метаболитов растительных объектов in vitro, для защиты населения от преждевременного старения» (проект FZSR-2024-0008) с использованием оборудования ЦКП «Инструментальные методы анализа в области прикладной биотехнологии» на базе КемГУ.
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Литература
Список литературы
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