ОЦЕНКА БЕЗОПАСНОСТИ РЯДА РАСТИТЕЛЬНЫХ МЕТАБОЛИТОВ – ПЕРСПЕКТИВНЫХ ГЕРОПРОТЕКТОРОВ В ИССЛЕДОВАНИИ IN VIVO

Ключевые слова: токсикологическая безопасность, мутагенные и антимутагенные свойства, цитотоксичность, полифенольные соединения

Аннотация

Обоснование. Старение происходит наряду с прогрессирующим снижением физических функций организма и повышенным риском возрастных хронических заболеваний. Для лечения и профилактики хронических заболеваний в том числе используют полифенолы, например, мангиферин, кверцетин и транс-коричная кислота. Токсикологические исследования имеют важное значение в сфере биомедицинских исследований, так как некоторые экстрагированные полифенолы в высоких дозах могут способствовать развитию и прогрессированию рака и других заболеваний. Настоящее исследование направлено на оценку токсикологической безопасности выделенных ранее фенольных соединений из растений Сибирского Федерального округа.

Материалы и методы. В качестве модельного организма выбраны грызуны. Изучение мутагенных и антимутагенных свойств проводили при помощи микроядерного теста клеток костного мозга. Оценку цитотоксичности in vitro вели с помощью МТТ-теста.

Результаты. Изученные полифенолы в дозах 50,0 и 100,0 мг/кг не обладают мутагенными свойствами. Мангифери и кверцетин в дозе 50,0 мг/кг не обладают антимутагенным действием. При этом транс-коричная кислота в той же концентрации обладает антимутагенными действием. Мангиферин в концентрациях от 4,2 до 16,7 мкг/мл оказывает цитотоксическое действие. Транс-коричная кислота не обладает цитотоксичностью (при 2,1–33,3 мкг/мл). Кверцетин в концентрации 0,21 и 1,67 мкг/мл цитотоксическое действие, а в концентрациях 3,33 мкг/мл увеличивает жизнеспособность спленоцитов, предположительно за счет антиоксидантных свойств.

Заключение. Безопасность или низкая токсичность являются решающим преимуществом дальнейшего использования полифенолов в качестве перспективных геропротекторов. Установлено, что дальнейшее изучение биологически активных веществ (мангиферина, кверцетина и транс-коричной кислоты) является целесообразным.

Работа выполнена в рамках государственного задания по теме «Разработка биологически активных добавок, состоящих из метаболитов растительных объектов in vitro, для защиты населения от преждевременного старения» (проект FZSR-2024-0008) с использованием оборудования ЦКП «Инструментальные методы анализа в области прикладной биотехнологии» на базе КемГУ.

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Биографии авторов

Anna S. Frolova, Кемеровский государственный университет

младший научный сотрудник Лаборатории биотестирования природных нутрицевтиков

Irina S. Milentyeva, Кемеровский государственный университет

доктор технических наук, заведующий Лабораторией биотестирования природных нутрицевтиков

Anastasia M. Fedorova, Кемеровский государственный университет

кандидат биологических наук, младший научный сотрудник Лаборатории биотестирования природных нутрицевтиков

Lyudmila K. Asyakina, Кемеровский государственный университет

доктор технических наук, заведующий Лабораторией фиторемедиации техногенно нарушенных экосистем

Aleksandr Yu. Prosekov, Кемеровский государственный университет

доктор технических наук, доктор биологических наук, ректор, член-корреспондент РАН

Литература

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Опубликован
2024-06-30
Как цитировать
Frolova, A., Milentyeva, I., Fedorova, A., Asyakina, L., & Prosekov, A. (2024). ОЦЕНКА БЕЗОПАСНОСТИ РЯДА РАСТИТЕЛЬНЫХ МЕТАБОЛИТОВ – ПЕРСПЕКТИВНЫХ ГЕРОПРОТЕКТОРОВ В ИССЛЕДОВАНИИ IN VIVO. Siberian Journal of Life Sciences and Agriculture, 16(3), 64-91. https://doi.org/10.12731/2658-6649-2024-16-3-1146
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Междисциплинарные исследования