Бактериоцины для сельского хозяйства и аквакультуры
Аннотация
Обоснование. Обострение проблемы антимикробной резистентности, вызванной нерациональным использованием антибиотиков в сельском хозяйстве и аквакультуре, обуславливает необходимость поиска устойчивых и безопасных альтернатив. Бактериоцины представляют собой рибосомно синтезируемые антимикробные пептиды бактериального происхождения – класс природных соединений для борьбы с резистентными патогенами, обладающий минимальным воздействием на окружающую среду. В данном обзоре исследуется комплексный потенциал применения бактериоцинов в качестве альтернативы антибиотикам. Проведен детальный анализ структурного разнообразия, подходов к классификации и установленных механизмов антимикробного действия, включая нарушение целостности клеточной мембраны, ингибирование синтеза клеточной стенки, а также подавление синтеза нуклеиновых кислот и белков. Определены ключевые продуцирующие бактериоцины роды (Bacillus, Streptomyces и Pseudomonas) и их биологически активные метаболиты. Проанализировано применение бактериоцинов в сельском хозяйстве, в частности их роль в качестве агентов биоконтроля фитопатогенов, стимуляторов роста растений, а также средств улучшения здоровья и продуктивности сельскохозяйственных животных и птиц. Рассмотрен их потенциал в аквакультуре для контроля заболеваний (направленных против таких патогенов, как Vibrio spp., Aeromonas spp., Yersinia ruckeri), улучшения качества воды и консервации кормов, что способствует сокращению зависимости от превентивного использования антибиотиков. Несмотря на значительные достижения, сохраняются проблемы, связанные с оценкой эффективности in vivo, разработкой систем доставки, возможностью развития резистентности и регуляторными аспектами. Решение этих вопросов является ключевым условием для реализации потенциала бактериоцинов в качестве экологически безопасных инструментов обеспечения продовольственной безопасности и устойчивого развития наземных и аквакультурных систем.
Цель. Провести комплексный анализ потенциала применения бактериоцинов в качестве альтернативы антибиотикам в сельском хозяйстве и аквакультуре, обобщив данные об их классификации, механизмах действия, основных продуцентах и направлениях использования.
Материалы и методы. Проведен обзор и анализ современных научных литературных источников, посвященных бактериоцинам, их продуцентам (включая роды Bacillus, Streptomyces, Pseudomonas), механизмам антимикробного действия и практическому применению в агросекторе и аквакультуре.
Результаты. Систематизированы данные о структурном разнообразии и классификации бактериоцинов. Подробно описаны установленные механизмы их антимикробного действия, включая нарушение целостности клеточной мембраны, ингибирование синтеза клеточной стенки, нуклеиновых кислот и белков. Выявлены ключевые роды бактерий-продуцентов и охарактеризованы их биологически активные метаболиты. Проанализированы возможности применения бактериоцинов в растениеводстве в качестве агентов биоконтроля фитопатогенов и стимуляторов роста растений, а также в животноводстве и птицеводстве для улучшения здоровья и продуктивности. Рассмотрен потенциал бактериоцинов в аквакультуре для контроля заболеваний (включая патогены Vibrio spp., Aeromonas spp., Yersinia ruckeri), улучшения качества воды и консервации кормов.
Заключение. Бактериоцины представляют собой экологичную альтернативу традиционным антибиотикам для повышения продуктивности и устойчивости агро- и аквасистем. Реализация их потенциала требует решения задач, связанных с оценкой эффективности in vivo, разработкой систем доставки, изучением рисков развития резистентности и преодолением регуляторных барьеров.
EDN: OXIRFN
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