ПРОГНОЗИРОВАНИЕ УРОВНЯ МИКРОЭЛЕМЕНТНОГО ПИТАНИЯ ПЛОДА У ГЛУБОКОСТЕЛЬНЫХ КОРОВ
Аннотация
Считают, что внутриутробный запас микроэлементов, необходимых для нормального формирования и развития плода у крупного рогатого скота определяется уровнем питания и тканевыми депо матери. Нарушения микроэлементного питания негативно влияют на здоровье плода и после рождения, ограничивая его рост и предрасполагая к целому ряду соматических заболеваний. Поэтому прогнозирование и своевременная коррекция нарушений микроэлементного питания плода у крупного рогатого скота является актуальной задачей для зооветеринарной науки. В настоящем исследовании авторами впервые была предпринята попытка спрогнозировать уровень накопления селена (Se), меди (Cu), цинка (Zn), железа (Fe), хрома (Cr), стронция (Sr), молибдена (Mo), кобальта (Co), никеля (Ni), мышьяка (As) и марганца (Mn) в организме плода по содержанию этих микроэлементов в волосе матери за 60 дней до предполагаемого отела. Были обследованы 35 клинически здоровых коров симментальской породы с одноплодной беременностью и полученные от них телята (18 самцов и 17 самок). Для ретроспективной оценки микроэлементного статуса плода исследовали образцы волос, полученные у телят вскоре после рождения. Количественное определение микроэлементов (Se, Cu, Zn, Fe, Cr, Sr, Mo, Co, Ni, As и Mn) в образцах волос проводили методом масс-спектрометрии с индуктивно связанной плазмой (Nexion 300D, Perkin Elmer, США). Установлено, что закономерности распределения микроэлементов в системе «мать-плод» у крупного рогатого скота не связаны с полом новорожденного. Зависимости между содержанием в волосе матери и новорожденного для большинства исследованных микроэлементов удалось описать полиномами первого (Sr), второго (Co, Mn) и третьего порядка (Se, Cu, Zn, Fe, As). Для четырех микроэлементов (Se, Cu, Fe и Co) получены графики и аналитические выражения, позволяющие прогнозировать по показателям матери их содержание в организме плода с уровнем статистической значимости Р = 0,05, для других четырех микроэлементов (Zn, Sr, As и Mn) – с уровнем Р от 0,10 до 0,15. Для Mo, Cr и Ni статистически значимые зависимости между содержанием их в волосе матери и новорожденного выявить не удалось. На основании полученных прогнозирующих зависимостей для 8 из 11 исследованных микроэлементов (Se, Cu, Fe, Co, Zn, Sr, As и Mn) определены интервалы содержания в волосе коровы за 60 дней до предполагаемого отела, обеспечивающие оптимальный уровень их накопления в организме плода.
Информация о спонсорстве. Исследование выполнено при финансовой поддержке гранта Российского научного фонда (проект № 23-26-00136).
Скачивания
Литература
Список литературы
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Safonov V.A., Mikhalev V.I., Chernitskiy A.E. Antioxidant status and functional condition of respiratory system of newborn calves with intrauterine growth retardation // Agricultural Biology, 2018, vol. 53, no. 4, pp. 831-841. https://doi.org/10.15389/agrobiology.2018.4.831eng
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Shabunin S., Nezhdanov A., Mikhalev V., Lozovaya E., Chernitskiy A. Diselementosis as a risk factor of embryo loss in lactating cows // Turkish Journal of Veterinary and Animal Sciences, 2017, vol. 41, no. 4, pp. 453-459. http://dx.doi.org/10.3906/vet-1609-76
Sullivan T.M., Micke G.C., Greer R.M., Irving-Rodgers H.F., Rodgers R.J., Perry V.E. Dietary manipulation of Bos indicus x heifers during gestation affects the reproductive development of their heifer calves // Reproduction Fertility and Development, 2009, vol. 21, no. 6, pp. 773-784. https://doi.org/10.1071/RD09004
Suttle N.F. Mineral Nutrition of Livestock. 5th ed. Boston: CABI, 2022. 600 p. http://dx.doi.org/10.1079/9781789240924.0000
Van Emon M., Sanford C., McCoski S. Impacts of bovine trace mineral supplementation on maternal and offspring production and health // Animals, 2020, vol. 10, no. 12, 2404. https://doi.org/10.3390/ani10122404
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Kalaeva E., Kalaev V., Chernitskiy A., Alhamed M., Safonov V. Incidence risk of bronchopneumonia in newborn calves associated with intrauterine diselementosis. Veterinary World, 2020, vol. 13, no. 5, pp. 987-995. https://doi.org/10.14202/vetworld.2020.987-995
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McCarthy K.L., Undi M., Becker S., Dahlen C.R. Utilizing an electronic feeder to measure individual mineral intake, feeding behavior, and growth performance of cow-calf pairs grazing native range. Translational Animal Science, 2021, vol. 5, no. 1, txab007. https://doi.org/10.1093/tas/txab007
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Mehdi Y., Dufrasne I. Selenium in cattle: a review. Molecules, 2016, vol. 21, no. 4, 545. https://doi.org/10.3390/molecules21040545
Miroshnikov S.A., Skalny A.V., Zavyalov O.A., Frolov A.N., Grabeklis A.R. The reference values of hair content of trace elements in dairy cows of Holstein breed. Biological Trace Element Research, 2020, vol. 194, no. 1, pp. 145-151. https://doi.org/10.1007/s12011-019-01768-6
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Nezhdanov A.G., Mikhalev V.I., Chusova G.G., Papin N.E., Chernitskiy A.E., Lozovaya E.G. Metabolic status of the cows under intrauterine growth retardation of embryo and fetus. Agricultural Biology, 2016, vol. 51, no. 2, pp. 230-237. https://doi.org/10.15389/agrobiology.2016.2.230eng
Ojeda M.L., Nogales F., Romero-Herrera I., Carreras O. Fetal programming is deeply related to maternal selenium status and oxidative balance; experimental offspring health repercussions. Nutrients, 2021, vol. 13, no. 6, 2085. https://doi.org/10.3390/nu13062085
Safonov V., Salimzade E., Ermilova T., Chernitskiy A. Retrospective diagnosis of intrauterine diselementosis in newborn calves. BIO Web of Conferences, 2022, vol. 52, 00033. https://doi.org/10.1051/bioconf/20225200033
Safonov V.A., Mikhalev V.I., Chernitskiy A.E. Antioxidant status and functional condition of respiratory system of newborn calves with intrauterine growth retardation. Agricultural Biology, 2018, vol. 53, no. 4, pp. 831-841. https://doi.org/10.15389/agrobiology.2018.4.831eng
Nakamura T., Yamada T., Kataoka K., Sera K., Saunders T., Takatsuji T., Makie T., Nose Y. Statistical resolutions for large variabilities in hair mineral analysis. PLoS One, 2018, vol. 13, no. 12, e0208816. https://doi.org/10.1371/journal.pone.0208816
Shabunin S., Nezhdanov A., Mikhalev V., Lozovaya E., Chernitskiy A. Diselementosis as a risk factor of embryo loss in lactating cows. Turkish Journal of Veterinary and Animal Sciences, 2017, vol. 41, no. 4, pp. 453-459. http://dx.doi.org/10.3906/vet-1609-76
Sullivan T.M., Micke G.C., Greer R.M., Irving-Rodgers H.F., Rodgers R.J., Perry V.E. Dietary manipulation of Bos indicus x heifers during gestation affects the reproductive development of their heifer calves. Reproduction Fertility and Development, 2009, vol. 21, no. 6, pp. 773-784. https://doi.org/10.1071/RD09004
Suttle N.F. Mineral Nutrition of Livestock. 5th ed. Boston: CABI, 2022. 600 p. http://dx.doi.org/10.1079/9781789240924.0000
Van Emon M., Sanford C., McCoski S. Impacts of bovine trace mineral supplementation on maternal and offspring production and health. Animals, 2020, vol. 10, no. 12, 2404. https://doi.org/10.3390/ani10122404
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