МАЛЫЕ МОЛЕКУЛЫ В ТЕСТЕ ИНГИБИРОВАНИЯ БАКТЕРИАЛЬНОЙ ЛЮМИНЕСЦЕНЦИИ
Аннотация
Состояние вопроса. Отказ от антибиотиков в животноводстве побуждает к поиску новых более эффективных альтернатив, одной из которых являются фитохимические вещества – малые молекулы с выраженным биоактивным действием.
Материалы и методы. В статье рассмотрены физиологические свойства кверцетина, 7-гидроксикумарина, ванилина, транс-коричного альдегида, как действующих веществ из экстрактов некоторых растений. Проведена их биологическая аттестация в тесте ингибирования бактериальной люминесценции с применением рекомбинантного штамма Escherichia coli K12 TG1 в сравнении с антибиотическим препаратом тетрациклином.
Результаты. Установлены эффективные концентрации кверцетина, 7-гидроксикумарина, ванилина, транс-коричного альдегида, подавляющие 80, 50 и 20 % свечения в двух средах – H2O и рубцовой жидкости, составляющие, соответственно в первом случае 9,8×10-4; 4,9×10-4; 6,1×10-5 моль/л для транс-коричного альдегида; 3,9×10-3; 1,9×10-3; 4,9×10-4 моль/л для ванилина; 2,5×10-1; 1,2×10-1; 9,8×10-4 моль/л для кверцетин дигидрата; 1,6×10-2; 9,8×10-4; 4,9×10-4 моль/л для 7-гидроксикумарина.
Заключение. Транс-коричный альдегид, ванилин, 7-гидроксикумарин и кверцетин обладают выраженным бактерицидным или бактериостатическим действием и могут быть использованы как альтернатива антибиотических препаратов в кормлении сельскохозяйственных животных, включая крупный рогатый скот. В частности, в среде рубцового содержимого наблюдается синергетически усиливающееся подавление бактериального штамма.
Скачивания
Литература
Список литературы
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