ОСОБЕННОСТИ МЕТАБОЛИЗМА И ПОТЕНЦИАЛЬНАЯ РОЛЬ НЕЙРОТРОФИЧЕСКИХ ФАКТОРОВ ГОЛОВНОГО МОЗГА В РЕАБИЛИТАЦИОННОМ ПРОЦЕССЕ
Аннотация
Понимание метаболических путей регуляции и взаимодействия нейротрофических факторов важно с точки зрения обсуждения нейротрофических факторов в качестве биологических маркеров, отражающих динамику и эффективность реабилитационного процесса.
Цель работы – проанализировать особенности продукции, метаболизма, механизмов действия основных нейротрофических факторов, которые могут объяснить возможность их активного вовлечения в реабилитационный процесс пациентов с детским церебральным параличом. В статье представлен анализ литературы о метаболизме нейротрофических факторов головного мозга (фактор роста головного мозга BDNF, нейротрофины NT-3 и NT4/5, фактор роста фибробластов FGF-1 и FGF-2, фактор роста нервов NGF, инсулиноподобный фактор роста IGF1, глиальный нейротрофический фактор GDNF, цилиарный нейротрофический фактор CNTF). Приводятся сведения об особенностях их продукции, взаимосвязи между профакторами и зрелыми формами, а также о специфике взаимодействия с рецепторами. Заключение. Статистически значимое падение уровней нейротрофических факторов на фоне реабилитационной терапии детей с ДЦП с применением программно-аппаратного комплекса «НИМК – экзокисть-2» отражает активное вовлечение нейротрофических факторов в данный процесс. Спектр биологических эффектов нейтротрофических факторов позволяет рассматривать весь многокомпонентный механизм, происходящий в головном мозге в процессе функциональной перестройки, как достаточный для реабилитационного восстановления.
Скачивания
Литература
Список литературы
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