ВЛИЯНИЕ ПРОФИЛАКТИЧЕСКОГО ПРИМЕНЕНИЯ ЦИНКА НА ОКИСЛИТЕЛЬНО-ВОССТАНОВИТЕЛЬНЫЙ СТАТУС В МОДЕЛИ MAFLD
Аннотация
Обоснование. Окислительный стресс играет важную роль в патогенезе метаболически-ассоциированной жировой болезни печени (MAFLD). В этом процессе участвуют антиоксидантные микроэлементы в качестве кофакторов и металлопротеинов. Цинк, являясь важным антиоксидантом, может оказывать положительное дейсткие при патологии печени.
Цель. Оценить влияние профилактического применения цинка на некоторые окислительно-восстановительные параметры ми морфологию печения на модели MAFLD у крыс.
Материалы и методы. В исследовании использовали 26 трехмесячных самок крыс линии Вистар. Оценивали активность супероксиддисмутазы и каталазы, содержание церулоплазмина, окисленного триптофана, дитирозинов, общих тиоловых и карбонильных соединений, ТБК-РС и мочевую кислоту на спектрофотометре. Статистическая обработка данных осуществлялась с помощью RStudio для MacOS (версия 1.3.1056).
Результаты. MAFLD сопровождалась гиперурикемией и снижением уровня дитирозинов в сыворотке крови. Добавление Zn в рацион предотвращало развитие стеатоза, снижало уровень окисленного триптофана в печени, но вызывало гиперурикемию в используемой модели MAFLD. Применение цинка оказало положительный эффект при профилактике MAFLD, мало влияло на окислительно-восстановительный статус животных, но вызвало парадоксальную гиперурикемию. Поэтому, необходимы дальнейшие исследования для установления механизмов действия цинка на клеточном уровне.
Скачивания
Литература
References
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Список литературы
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Ohkawa, H., Ohishi, N., & Yagi, K. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction // Analytical biochemistry, 1979, vol. 95, no. 2, pp. 351-358. https://doi.org/10.1016/0003-2697(79)90738-3
Olechnowicz, J., Tinkov, A., Skalny, A., & Suliburska, J. Zinc status is associated with inflammation, oxidative stress, lipid, and glucose metabolism // The Journal of Physiological Sciences, 2018, vol. 68, no. 1, pp. 19-31.
Oral, A., Sahin, T., Turker, F., & Kocak, E. Relationship between serum uric acid levels and nonalcoholic fatty liver disease in non-obese patients // Medicina, 2019, vol. 55, no. 9, pp. 600. https://doi.org/10.3390/medicina55090600
Oteiza, P. I. Zinc and the modulation of redox homeostasis // Free Radic. Biol. Med, 2012, vol. 53, no. 9, pp. 1748-1759. https://doi.org/10.1007/s12576-017-0571-7
Prasad, A. S. (Ed.). Essential and toxic element: trace elements in human health and disease. Elsevier, 2013.
Ravin, H. A. An improved colorimetric enzymatic assay of ceruloplasmin // The Journal of laboratory and clinical medicine, 1961, vol. 58, no. 1, pp. 161-168. https://doi.org/10.5555/uri:pii:0022214361901391
Sies, H., Jones, D. P. Reactive oxygen species (ROS) as pleiotropic physiological signalling agents // Nature reviews Molecular cell biology, 2020, vol. 21, no. 7, pp. 363-383. https://doi.org/10.1038/s41580-020-0230-3
So, A., Thorens, B. Uric acid transport and disease // The Journal of clinical investigation, 2010, vol. 120, no. 6, pp. 1791-1799. https://doi.org/10.1172/jci42344
Song M., Vos M., Mcclain C. Copper-fructose interactions: a novel mechanism in the pathogenesis of NAFLD // Nutrients. 2018; 10: 1815.
Tilg H., Effenberger M. From NAFLD to MAFLD: when pathophysiology succeeds // Nature reviews Gastroenterology & hepatology, 2020, vol. 17, no. 7, pp. 387-388. https://doi.org/10.1038/s41575-020-0316-6
Umeki S., Ohga R., Konishi Y., Yasuda T., Morimoto K., Terao A. Oral zinc therapy normalizes serum uric acid level in Wilson’s disease patients // The American journal of the medical sciences, 1986, vol. 292, no. 5, pp. 289-292. https://doi.org/10.1097/00000441-198611000-00007
Ushijima Y., Nakano M., Goto T. Production and identification of bityrosine in horseradish peroxidase-H2O2-tyrosine system // Biochemical and biophysical research communications, 1984, vol. 125, no. 3, pp. 916-918. https://doi.org/10.1016/0006-291X(84)91370-6
Videla L. A., Rodrigo R., Orellana M., Fernandez V., Tapia G., Quiñones L., ... Poniachik J. Oxidative stress-related parameters in the liver of non-alcoholic fatty liver disease patients // Clinical science, 2004, vol. 106, no. 3, pp. 261-268. https://doi.org/10.1042/CS20030285
Yesilova Z., Yaman H., Oktenli C., Ozcan A., Uygun A., Cakir E., ... Dagalp K. Systemic markers of lipid peroxidation and antioxidants in patients with nonalcoholic fatty liver disease // Official journal of the American College of Gastroenterology| ACG, 2005, vol. 100, no. 4, pp. 850-855. https://doi.org/10.1111/j.1572-0241.2005.41500.x
Zhang Y., Liu Y., Qiu H. Association between dietary zinc intake and hyperuricemia among adults in the United States // Nutrients, 2018, vol. 10, no. 5, pp. 568.
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