ВЛИЯНИЕ КУМАРИНА НА ПРОДУКТИВНОСТЬ, ИММУНИТЕТ И АНТИОКСИДАНТНЫЙ СТАТУС ЗДОРОВЫХ ЦЫПЛЯТ-БРОЙЛЕРОВ
Аннотация
Обоснование. Кумарины – природные соединения (вторичные метаболиты растительного происхождения) обладают широким спектром биологической активности, в основном благодаря их способности взаимодействовать с разнообразными ферментами и рецепторами в живых организмах. Актуальность их использования в кормлении сельскохозяйственной птицы очевидна, ввиду активного поиска альтернатив кормовым антибиотикам.
Целью исследования явилась оценка влияния кумарина на продуктивность и антиоксидантный статус цыплят-бройлеров.
Материалы и методы. Объекты исследования: цыплята-бройлеры кросса Арбор Айкрес, 7-Гидроксикумарин. Эксперимент проведен на 180 головах 7-дневных цыплят-бройлеров (n=45). Контрольная – основной рацион (ОР), 1 опытная – ОР + кумарин (в дозе 1 мг/кг корма /сут., 2 опытная – ОР + кумарин в дозе 2 мг/кг корма /сут., 3 опытная – ОР + кумарин в дозе 3 мг/кг корма /сут. Гематологические показатели (число и вид лейкоцитов) учитывали на автоматическом гематологическом анализаторе URIT-2900 Vet Plus («URIT Medical Electronic Group Co., Ltd», Китай). Биохимический анализ сыворотки крови проводили на автоматическом биохимическом анализаторе CS-T240 (“Dirui Industrial Co., Ltd”, Китай).
Результаты. Включение в рацион 7-гидроксикумарина способствовало увеличению живой массы в опытных группах – на 8,6–19,4%; потреблению корма, среднесуточного прироста (на 9,2–21,1%), убойного выхода (до 4,76%), на фоне снижения расхода корма на 1 кг прироста живой массы (на 3,5–15,7%). Анализ биохимических показателей сыворотки крови показал снижение показателей общего белка, альбуминов, АЛТ (1 и 2 группа (p≤0,05)), билирубина (на 38,3–68,6%), холестерина (в 3 группе на 16,4% (p≤0,05)), триглицеридов (1 и 2 группы, p≤0,05), мочевины (41,8–65,1%; p≤0,05), на фоне повышенного уровня железа (1 и 2 группы, p≤0,05). В зависимости от дозы 7-гидроксикумарина установлено снижение количества лейкоцитов (1 группа, p≤0,05), нейтрофилов (1 и 2 группа, p≤0,05), моноцитов, эозинофилов и базофилов (p≤0,05). Антиоксидантные показатели характеризовались снижением уровня малонового диальдегида (на 63,7–77,3%), активности супероксиддисмутазы (22,4–71,5%) и увеличением активности каталазы (на 24,3–46,1%).
Заключение. Включение в рацион 7-гидроксикумарина (2 мг/кг корма /сут.) способствовало увеличению живой массы цыплят-бройлеров, поедаемости корма, убойного выхода, на фоне более низкого расхода корма на прирост 1 кг живой массы; положительно повлияло на показатели печени (АЛТ, общий билирубин), липидного и азотистого обмена (триглицериды, мочевина), антиоксидантный статус организма цыплят-бройлеров.
Скачивания
Литература
Список литературы
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Ma J., Li C.J., Yang J.Z., Sun H., Zhang D.M. New Phenylpropanoid and Coumarin Glycosides from the Stems of Hydrangea paniculata Sieb. Molecules, 2017, vol. 22(1), pp. 1-12. https://doi.org/10.3390/molecules22010133
Mu C., Wu M., Li Z. Anti-Inflammatory Effect of Novel 7-Substituted Coumarin Derivatives through Inhibition of NF-κB Signaling Pathway. Chemistry and Biodiversity, 2019, vol. 16(3), pp. e1800559. https://doi.org/10.1002/cbdv.201800559
Murayama N., Yamazaki H. Metabolic activation and deactivation of dietary-derived coumarin mediated by cytochrome P450 enzymes in rat and human liver preparations. The Journal of Toxicological Sciences, 2021, vol. 46(8), pp. 371-378. https://doi.org/10.2131/jts.46.371
Pei Q., Hu P., Zhang H., Li H., Yang T., Liu R. Daphnetin exerts an anticancer effect by attenuating the pro-inflammatory cytokines. Journal of Biochemical and Molecular Toxicology, 2021, vol. 35(6), pp. 1-8. https://doi.org/10.1002/jbt.22759
Petrovic V., Marcincak S., Popelka P., Simkova J., Martonova M., Buleca J., Marcincakova D., Tuckova M., Molnar L., Kovac G. The effect of supplementation of clove and agrimony or clove and lemon balm on growth perfor-mance, antioxidant status and selected indices of lipid profile of broiler chickens. Journal of Animal Physiology and Animal Nutrition, 2012, vol. 96(6), pp. 970-977. https://doi.org/10.1111/j.1439-0396.2011.01207.x
Qin H.L., Zhang Z.W., Ravindar L., Rakesh K.P. Antibacterial activities with the structure-activity relationship of coumarin derivatives. European Journal of Medicinal Chemistry, 2020, vol. 207, pp. 112832. https://doi.org/10.1016/j.ejmech.2020.112832
Reen F.J., Gutiérrez-Barranquero J.A., Parages M.L., O Gara F. Coumarin: a novel player in microbial quorum sensing and biofilm formation inhibition. Applied Microbiology and Biotechnology, 2018, vol. 102(5), pp. 2063-2073. https://doi.org/10.1007/s00253-018-8787-x
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