ВЛИЯНИЕ КУМАРИНА НА ПРОДУКТИВНОСТЬ, ИММУНИТЕТ И АНТИОКСИДАНТНЫЙ СТАТУС ЗДОРОВЫХ ЦЫПЛЯТ-БРОЙЛЕРОВ

  • Galimzhan K. Duskaev ФГБНУ Федеральный научный центр биологических систем и агротехнологий Российской академии наук https://orcid.org/0000-0002-9015-8367
  • Tatyana A. Klimova ФГБНУ Федеральный научный центр биологических систем и агротехнологий Российской академии наук https://orcid.org/0000-0003-4298-1663
Ключевые слова: цыплята-бройлеры, кумарин, живая масса, биохимия крови, антиоксидантные показатели, белые клетки крови

Аннотация

Обоснование. Кумарины – природные соединения (вторичные метаболиты растительного происхождения) обладают широким спектром биологической активности, в основном благодаря их способности взаимодействовать с разнообразными ферментами и рецепторами в живых организмах. Актуальность их использования в кормлении сельскохозяйственной птицы очевидна, ввиду активного поиска альтернатив кормовым антибиотикам.

Целью исследования явилась оценка влияния кумарина на продуктивность и антиоксидантный статус цыплят-бройлеров.

Материалы и методы. Объекты исследования: цыплята-бройлеры кросса Арбор Айкрес, 7-Гидроксикумарин. Эксперимент проведен на 180 головах 7-дневных цыплят-бройлеров (n=45). Контрольная – основной рацион (ОР), 1 опытная – ОР + кумарин (в дозе 1 мг/кг корма /сут., 2 опытная – ОР + кумарин в дозе 2 мг/кг корма /сут., 3 опытная – ОР + кумарин в дозе 3 мг/кг корма /сут. Гематологические показатели (число и вид лейкоцитов) учитывали на автоматическом гематологическом анализаторе URIT-2900 Vet Plus («URIT Medical Electronic Group Co., Ltd», Китай). Биохимический анализ сыворотки крови проводили на автоматическом биохимическом анализаторе CS-T240 (“Dirui Industrial Co., Ltd”, Китай).

Результаты. Включение в рацион 7-гидроксикумарина способствовало увеличению живой массы в опытных группах – на 8,6–19,4%; потреблению корма, среднесуточного прироста (на 9,2–21,1%), убойного выхода (до 4,76%), на фоне снижения расхода корма на 1 кг прироста живой массы (на 3,5–15,7%). Анализ биохимических показателей сыворотки крови показал снижение показателей общего белка, альбуминов, АЛТ (1 и 2 группа (p≤0,05)),  билирубина (на 38,3–68,6%), холестерина (в 3 группе на 16,4% (p≤0,05)), триглицеридов (1 и 2 группы, p≤0,05), мочевины (41,8–65,1%; p≤0,05), на фоне повышенного уровня железа (1 и 2 группы, p≤0,05). В зависимости от дозы 7-гидроксикумарина установлено снижение количества лейкоцитов (1 группа, p≤0,05), нейтрофилов (1 и 2 группа, p≤0,05), моноцитов, эозинофилов и базофилов (p≤0,05). Антиоксидантные показатели характеризовались снижением уровня малонового диальдегида (на 63,7–77,3%), активности супероксиддисмутазы (22,4–71,5%) и увеличением активности каталазы (на 24,3–46,1%).

Заключение. Включение в рацион 7-гидроксикумарина (2 мг/кг корма /сут.) способствовало увеличению живой массы цыплят-бройлеров, поедаемости корма, убойного выхода, на фоне более низкого расхода корма на прирост 1 кг живой массы; положительно повлияло на показатели печени (АЛТ, общий билирубин), липидного и азотистого обмена (триглицериды, мочевина), антиоксидантный статус организма цыплят-бройлеров.

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Биографии авторов

Galimzhan K. Duskaev, ФГБНУ Федеральный научный центр биологических систем и агротехнологий Российской академии наук

доктор биологических наук, профессор РАН, первый заместитель директора

Tatyana A. Klimova, ФГБНУ Федеральный научный центр биологических систем и агротехнологий Российской академии наук

младший научный сотрудник

Литература

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Liu H.S., Mahfuz S.U., Wu D., Shang Q.H., Piao X.S. Effect of chestnut wood extract on performance, meat quality, antioxidant status, immune function, and cholesterol metabolism in broilers. Poultry Science, 2020, vol. 99(9), pp. 4488-4495. https://doi.org/10.1016/j.psj.2020.05.053

Ma J., Li C.J., Yang J.Z., Sun H., Zhang D.M. New Phenylpropanoid and Coumarin Glycosides from the Stems of Hydrangea paniculata Sieb. Molecules, 2017, vol. 22(1), pp. 1-12. https://doi.org/10.3390/molecules22010133

Mu C., Wu M., Li Z. Anti-Inflammatory Effect of Novel 7-Substituted Coumarin Derivatives through Inhibition of NF-κB Signaling Pathway. Chemistry and Biodiversity, 2019, vol. 16(3), pp. e1800559. https://doi.org/10.1002/cbdv.201800559

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Опубликован
2023-06-30
Как цитировать
Duskaev, G., & Klimova, T. (2023). ВЛИЯНИЕ КУМАРИНА НА ПРОДУКТИВНОСТЬ, ИММУНИТЕТ И АНТИОКСИДАНТНЫЙ СТАТУС ЗДОРОВЫХ ЦЫПЛЯТ-БРОЙЛЕРОВ. Siberian Journal of Life Sciences and Agriculture, 15(3), 197-218. https://doi.org/10.12731/2658-6649-2023-15-3-197-218
Раздел
Сельскохозяйственные исследования

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