КЛИНИКО-ЛАБОРАТОРНЫЕ ОСОБЕННОСТИ ИММУННОГО ОТВЕТА У ДЕТЕЙ С ИНФЕКЦИЕЙ COVID-19
Аннотация
В статье представлены результаты анализа клинико-морфологической характеристики и ряда показателей периферической крови у детей с новой коронавирусной инфекцией.
Цель исследования – дать клинико-лабораторную характеристику иммунного ответа у детей с новой коронавирусной инфекцией.
Материалы и методы. Обследовано 102 детей с новой коронавирусной инфекцией. Оценка показателей периферической крови и субпопуляций лимфоцитов у детей трех возрастных групп 0-4 лет, 5-9 лет и 10-14 лет.
Результаты. У детей с новой коронавирусной инфекцией наблюдается дисбаланс гранулоцитарного и лимфоцитарного звена, наиболее выраженный для детей младшего (0-4 года) и среднего (5-9 лет) возрастной групп. Общая тенденция изменений характеризуется повышением лимфоцитов и гранулоцитов в начале заболевания и снижение через 2 недели. Коэффициент соотношения нейтрофилов к лимфоцитам демонстрирует преобладание нейтрофилов.
Заключение. Наше исследование продемонстрировало, что при острой фазе вирусной инфекции COVID-19 у детей происходит увеличение содержания нейтрофилов, относительно содержания лимфоцитов. При анализе показателей субпопуляций лимфоцитов у детей было установлено снижение Т-цитотоксических лимфоцитов (CD3+CD8+), NK-лимфоцитов (CD16+CD56+) и В-лимфоцитов (CD19+) относительно нормы. Исследования дают важные клинические данные во время продолжающейся пандемии.
Скачивания
Литература
Список литературы
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COVID-19 in children treated with immunosuppressive medication for kidney diseases / M. Marlais, T. Wlodkowski, S. Al-Akash, et al. Arch. Dis. Child., 2021, vol. 106, pp. 798–801.
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Detection of Covid-19 in Children in Early January 2020 in Wuhan, China. / W. Liu, Q. Zhang, J. Chen, et al. N. Engl. J. Med., 2020, vol. 382(14), pp. 1370-1371. https://doi.org/10.1056/NEJMc2003717
Effects of Coronavirus Disease 2019 (COVID-19) on Peripheral Blood Lymphocytes and Their Subsets in Children: Imbalanced CD4+/CD8+ T Cell Ratio and Disease Severity / S. Mahmoudi, B. Yaghmaei, M. Sharifzadeh Ekbatani, et al. Front. Pediatr., 2021, vol. 9, 643299, pp. 1-7. https://doi.org/10.3389/fped.2021.643299
Expansion of CD56dimCD16neg NK Cell Subset and Increased Inhibitory KIRs in Hospitalized COVID-19 Patients / J. L. Casado, E. Moraga, P. Vizcarra, et al. Viruses, 2022, vol. 14 (1), pp. 46. https://doi.org/10.3390/v14010046
Hematological parameters and peripheral blood morphologic abnormalities in children with COVID-19 / N. Yarali, Y. M. Akcabelen, Y. Unal, A. Ö. Parlakay. Authorea, 2020. https://doi.org/10.22541/au.159069193.34265275
https://covid.cdc.gov/covid-data-tracker/#pediatric-data
Kuklina E. M. T Lymphocytes as Targets for SARS-CoV-2. Biokhimiya, 2022, vol. 87, no. 6, pp. 780-793. https://doi.org/10.1134/s0006297922060086
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Neutrophil-to-lymphocyte ratio predicts critical illness patients with 2019 coronavirus disease in the early stage / J. Liu, Y. Liu, P. Xiang, et al. Journal of Translational Medicine, 2020, vol. 18(1), pp. 206–218. https://doi.org/10.1186/s12967-020-02374-0
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Perinatal Inflammation Influences but Does Not Arrest Rapid Immune Development in Preterm Babies / S. Kamdar, R. Hutchinson, A. Laing, et al. Nat. Commun., 2020, vol. 11, pp. 1284. https://doi.org/10.1038/s41467-020-14923-8
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SARS-CoV-2 infection in children / X. Lu, L. Zhang, H. Du, et al. N. Engl. J. Med., 2020, vol. 382(17), pp. 1663–1665. https://doi.org/10.1056/NEJMc2005073
Single-cell landscape of immunological responses in patients with COVID-19 / Ji.-Y. Zhang, X.-M. Wang, X. Xing, et al. Nature Immunology, 2020, vol. 21, pp. 1107–1118. https://doi.org/10.1038/s41590-020-0762-x
Susceptibility to SARS-CoV-2 Infection Among Children and Adolescents Compared With Adults: A Systematic Review and Meta-Analysis / R.M. Viner, O.T. Mytton, C. Bonell, et al. JAMA Pediatr., 2021, vol. 175, pp. 143–156. https://doi.org/10.1001/jamapediatrics.2020.4573
Systems serology detects functionally distinct coronavirus antibody features in children and elderly / K.J. Selva, C.E. van de Sandt, M.M. Lemke et al. Nat. Commun., 2021, vol. 12, pp. 2037. https://doi.org/10.1038/s41467-021-22236-7
The diagnostic and predictive role of NLR, d-NLR and PLR in COVID-19 patients / A-P. Yang, J. Liu, W. Tao, H. Li. International Immunopharmacology, 2020, vol. 84, pp. 106504. https://doi.org/10.1186/1755-7682-5-2
Validation of Predictors of Disease Severity and Outcomes in COVID-19 Patients: A Descriptive and Retrospective Study / L. Tan, X. Kang, X. Ji, et al. Med., 2020, vol.1 (1), pp. 128–138. https://doi.org/10.1016/j.medj.2020.05.002
Ying L. Developmental Differences in Focal Adhesion Kinase Expression Modulate Pulmonary Endothelial Barrier Function in Response to Inflammation / L. Ying, C.M. Alvira, D.N. Cornfield. Am. J. Physiol.-Lung Cell. Mol. Physiol., 2018, vol. 315, pp. L66–L77. https://doi.org/10.1152/ajplung.00363.2017
Zimmermann P. Why Is COVID-19 Less Severe in Children? A Review of the Proposed Mechanisms Underlying the Age-Related Difference in Severity of SARS-CoV-2 Infections / P. Zimmermann, N. Curtis. Arch. Dis. Child., 2020, vol. 106, pp. 429–439. https://doi.org/10.1136/archdischild-2020-320338
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